How Long Does Vyvanse Stay in Your System? December 6th, 2019 The Recovery Village at Palmer Lake
Blog & News How Long Does Vyvanse Stay in Your System?

How Long Does Vyvanse Stay in Your System?

Vyvanse is a prescription stimulant drug used primarily for the treatment of attention-deficit hyperactivity disorder (ADHD) in adults and children ages six and older. Vyvanse is also used to treat moderate-to-severe binge eating disorder (BED) in adults. The medication is taken orally and starts to work more slowly than similar drugs like Adderall. It can take around two hours for the effects of Vyvanse to occur, and effects may last up to 12 hours.

How long does Vyvanse stay in your system? The primary ingredient, lisdexamfetamine may fully clear from the system within an hour. However, lisdexamfetamine metabolizes to other substances, like dextroamphetamine, which have longer half-lives and stay in a person’s system longer.

What is Vyvanse?

What is Vyvanse? Vyvanse is a psychostimulant used for the treatment of ADHD and binge eating disorder. Because it affects the central nervous system, Vyvanse is similar to Adderall. It speeds-up central nervous system processes including heart rate and blood pressure in addition to improving focus and concentration and reducing appetite.

The difference between Adderall and Vyvanse lies primarily in the fact that Vyvanse is a prodrug. A prodrug isn’t active until it’s metabolized. This effect means Vyvanse has lower misuse and addiction potential than Adderall.

There are many strengths of Vyvanse available; from 20 mg up to 70 mg doses. Some of the off-label reasons Vyvanse may be prescribed for include treating depression and daytime sleepiness.

Vyvanse Half-Life

What’s the Vyvanse half-life? Half-life is an important measure when considering prescription medications. The half-life is a measure of how long it takes the concentration of a drug to be reduced in the system by half. It takes several half-lives for most drugs to leave the system fully.

When someone takes Vyvanse, the lisdexamfetamine metabolizes into dextroamphetamine. Dextroamphetamine has a longer half-life than lisdexamfetamine. The half-life of dextroamphetamine can range from 9 to 11 hours in the average user, which means it can take around 2.5 days for dextroamphetamine to clear the system.

How Long Does Vyvanse Stay in Urine?

A urine test is one way to screen for the use of certain substances. How long does Vyvanse stay in your urine? This answer varies depending on individual factors such as hydration and kidney function.

Amphetamines such as Vyvanse may show up on common urine drug screenings. Vyvanse could appear in urine for up to five days after someone takes it, although this can be shorter or longer depending on the person.

How Long Does Vyvanse Stay in Hair?

Another way to screen for the use of substances is a hair follicle test — although this is fairly uncommon. How long does Vyvanse stay in your hair? As with most substances, the use of amphetamines like Vyvanse may show up in a hair follicle test for up to 90 days after use. However, it can first take 1 to 2 weeks for the drug to show up in hair follicles after the latest use.

How Long Does Vyvanse Stay in Saliva?

How long does Vyvanse stay in your saliva? Saliva tests require the collection of fluid from a person’s mouth, but for the most part, these types of drug screenings have shorter detection windows than others. A saliva test might show the presence of dextroamphetamine for up to 48 hours after someone uses it.

How Long Does Vyvanse Stay in Blood?

Blood tests are another way to detect the use of substances, but they are invasive and have very short detection windows. How long does Vyvanse stay in your blood? It might show up for up to 24 hours after someone uses it, but sometimes the detection window is much shorter with a blood test.

Getting Treatment for Vyvanse Abuse

If you or someone you love struggles with Vyvanse abuse, contact The Recovery Village at Palmer Lake. Learn more about getting treatment for Vyvanse abuse and the types of programs that are available. You deserve a healthier future, call today.



Shire US Inc. “Vyvanse.” October 2018. Accessed April 17, 2019.

Healthy Place. “Lisdexamfetamine Dimesylate Full Prescribing Information.” HealthPlace, April 7, 2017. Accessed April 17, 2019.

Food and Drug Administration. “Vyvanse.” Accessed April 17, 2019.

Medical Disclaimer: The Recovery Village aims to improve the quality of life for people struggling with a substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider.