Wet Brain Syndrome

Written by Theresa Valenzky

& Medically Reviewed by Benjamin Caleb Williams, RN

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Last Updated - 09/12/2023

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Updated 09/12/2023

Wet brain, or Wernicke-Korsakoff syndrome caused by alcohol, has many side effects. If it is not properly treated early, it can cause permanent brain damage.

Wet brain, or wet brain syndrome, is a slang term for the medical condition called Wernicke-Korsakoff syndrome. This condition is caused by heavy alcohol use and leads to brain damage that can become permanent if not treated.

What Is Wet Brain?

Wet brain, or Wernicke-Korsakoff syndrome caused by alcohol use, is a type of brain damage caused by low levels of thiamine. Also called vitamin B1, thiamine is an essential nutrient for brain health and has severe impacts on the brain when deficiencies occur. While thiamine deficiencies can occur from starvation, they are often caused by heavy alcohol use.

Alcohol affects how the body absorbs thiamine, and people who misuse alcohol are also frequently malnourished, further increasing the problem. Thiamine deficiency causes inflammation called Wernicke encephalopathy. This inflammation eventually causes permanent damage called Korsakoff syndrome.

How Dangerous Is Wet Brain?

In severe cases, wet brain can lead to death in about 10–15% of cases. If untreated, wet brain can also lead to permanent brain damage that cannot be reversed, even if alcohol use is stopped and thiamine levels are fully replaced.

Who Is Most at Risk of Developing Wet Brain?

People who use alcohol heavily over a prolonged period of time are most at risk of developing wet brain. Heavy alcohol use is defined as drinking more than four drinks in one day or more than fourteen drinks in one week in men. For women, heavy alcohol use is considered drinking more than three drinks in one day or more than seven drinks in a week.

Can You Develop Wet Brain From Alcohol?

Wernicke-Korsakoff syndrome can occur from reasons other than alcohol use; however, the term “wet brain” is used to refer only to Wernicke-Korsakoff syndrome caused by alcohol use. Wet brain, by its definition, can only be caused by alcohol use. Not everyone who uses alcohol will develop wet brain, but the only way to get wet brain is by drinking alcohol.

Can Wet Brain Be Reversed?

Wet brain can be reversed if it is caught and treated early. Initially, wet brain leads to inflammation in the brain. If thiamine is given in these initial stages, wet brain can be quickly reversed. As the condition progresses, however, the inflammation leads to permanent damage. This cannot be reversed, even with treatment and alcohol cessation.

Wet Brain Stages

There are two stages to wet brain. The early stage, known as Wernicke encephalopathy, is more intense but reversible. The late sage, called Korsakoff syndrome, is permanent.

Wernicke Encephalopathy

Wernicke encephalopathy is the early stage of Wernicke-Korsakoff syndrome. This stage is caused by inflammation that occurs in the brain and is a temporary condition. Either Wernicke encephalopathy will transition into the second stage of wet brain and cause permanent brain damage, or it will be treated and resolved without causing damage. Wernicke encephalopathy can also lead to death and is considered the most dangerous stage of wet brain for quickly causing coma and death.

Korsakoff Psychosis

Korsakoff psychosis, also called Korsakoff syndrome, is the late stage of Wernicke-Korsakoff syndrome. This stage of wet brain results in permanent brain damage that cannot be treated. While Korsakoff psychosis is less likely to cause a coma or death than Wernicke encephalopathy, it is a form of brain damage that will normally require someone to be constantly taken care of.

Signs and Symptoms of Wet Brain

The symptoms of wet brain vary based on whether it is in the early, reversible stage or in the later, permanent stage.

Signs and Symptoms of Wernicke Encephalopathy

The symptoms of Wernicke encephalopathy include several symptoms. There is a “triad” of three symptoms considered to almost always occur with Wernicke encephalopathy. These include:

  • Altered mental status
  • Difficulty walking normally
  • Abnormalities in eye movement

Other signs of Wernicke encephalopathy include:

  • Confusion
  • Delirium
  • Memory problems
  • Decreased body temperature
  • Tremors
  • Coma

Signs and Symptoms of Korsakoff Psychosis

Korsakoff psychosis symptoms are permanent and primarily affect memory and perception of reality. Symptoms of Korsakoff psychosis include:

  • Confusion
  • Memory loss, especially difficulty forming new memories
  • Difficulty learning new skills
  • Personality changes
  • Inability to tell that memory problems exist
  • Difficulty concentrating

People with Korsakoff psychosis often experience confabulation, a condition in which someone subconsciously makes new memories to fill in gaps in the memory. Someone with confabulation will often repeat these made-up memories, thinking they are real. This gives them the appearance of lying when it is actually related to their brain damage.

Wet Brain Treatment

The treatment for wet brain is actually quite simple. Replacing thiamine will stop the progression of wet brain and reverse symptoms caused by its early stage. Stopping alcohol use will prevent wet brain from developing again or progressing further if it is already permanent.

Stopping alcohol use can be difficult, but it is essential if you are at risk of developing wet brain or have experienced it before. At The Recovery Village at Palmer Lake, we understand how stressful overcoming an alcohol addiction can be. Our caring staff provides state-of-the-art treatments to keep you as comfortable and safe as possible during alcohol withdrawal and beyond, supporting you with tools you need to achieve and maintain recovery.

Contact us today to learn how we can help you achieve lasting recovery from alcohol addiction.

If you know someone who abuses alcohol or you need help yourself, The Recovery Village at Palmer Lake can help. Our facility offers comprehensive treatment programs for each client’s unique needs. Take the first step toward recovery, and speak with a representative of The Recovery Village at Palmer Lake today.


Shelat, Amit M. “Wernicke-Korsakoff syndrome”>.” MedlinePlus, February 4, 2020. Accessed July 15, 2022.

Alcohol and Drug Foundation. “Alcohol and thiamine”>.” November 3, 2021. Accessed July 15, 2022.

Akhouri, Shweta; Kuhn, James; & Newton, Edward J. “Wernicke-Korsakoff Syndrome”>.” StatPearls, July 18, 2021. Accessed July 15, 2022.

National Institute on Alcohol Abuse and Alcoholism. “Drinking Levels Defined”>.” 2022. Accessed July 15, 2022.

Vasan, Sarayu & Kumar, Anil. “Wernicke Encephalopathy”>.” StatPearls, April 30, 2022. Accessed July 15, 2022.

O’Malley, Gerald F. & O’Malley, Rika. “Korsakoff Psychosis”>.” Merck Manuals, May 2020. Accessed July 15, 2022.

Salen, Philip N. “Wernicke Encephalopathy”>.” Medscape, November 20, 2018. Accessed July 15, 2022.

Alzheimer’s Society. “Wernicke–Korsakoff syndrome”>.” 2022. Accessed July 15, 2022.


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